Regeneration enhancers: A clue to reactivation of developmental genes
نویسندگان
چکیده
منابع مشابه
Transcriptional Enhancers in Protein-Coding Exons of Vertebrate Developmental Genes
Many conserved noncoding sequences function as transcriptional enhancers that regulate gene expression. Here, we report that protein-coding DNA also frequently contains enhancers functioning at the transcriptional level. We tested the enhancer activity of 31 protein-coding exons, which we chose based on strong sequence conservation between zebrafish and human, and occurrence in developmental ge...
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The genetic changes underlying the dramatic differences in form and function between humans and other primates are largely unknown, although it is clear that gene regulatory changes play an important role. To identify regulatory sequences with potentially human-specific functions, we and others used comparative genomics to find non-coding regions conserved across mammals that have acquired many...
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ژورنال
عنوان ژورنال: Development, Growth & Differentiation
سال: 2020
ISSN: 0012-1592,1440-169X
DOI: 10.1111/dgd.12654